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dc.contributoren-US
dc.creatorSiswanto, Agus; 1Faculty of Pharmacy, Gadjah Mada University, Sekip Utara Jogjakarta 55281, Indonesia 2Faculty of Pharmacy, Muhammadiyah University of Purwokerto, Jl. Raya Dukuh Waluh Purwokerto 53142, Indonesia
dc.creatorFudholi, Achmad; 1Faculty of Pharmacy, Gadjah Mada University, Sekip Utara Jogjakarta 55281, Indonesia
dc.creatorNugroho, Akhmad Kharis; 1Faculty of Pharmacy, Gadjah Mada University, Sekip Utara Jogjakarta 55281, Indonesia
dc.creatorMartono, Sudibyo; 1Faculty of Pharmacy, Gadjah Mada University, Sekip Utara Jogjakarta 55281, Indonesia
dc.date2015-04-04
dc.date.accessioned2019-10-29T03:14:50Z
dc.date.available2019-10-29T03:14:50Z
dc.identifierhttp://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/782
dc.identifier10.14499/indonesianjpharm26iss2pp94
dc.identifier.urihttp://r2kn.litbang.kemkes.go.id:8080/xmlui/handle/123456789/25152
dc.descriptionAspirin has low solubility in water therefore, dissolution is a rate limiting step for absorption. Floating tablet formulation is designed to improve the bioavailability of aspirin. The objective of this study was to determine in vitro dissolution study of aspirin floating tablet release kinetics model. The floating tablets were prepared by a direct compression method using Methocel K4M CR, NaHCO3, Ethocel, Aerosil, and dicalcium phospate anhydrous as excipients. Tablets were evaluated by different parameters such as physicochemical properties, floating lag time (Flag time), total floating time, and dissolution. The result showed that the tablet mass has good flow properties of 13.54 g/sec. Aspirin floating tablets had a weight uniformity (CV=1.45%), good hardness (6.42kg), and low friability (0.158%). The tablet has a short Flag time of 25.16 sec and long floating time of 8 hours. Dissolution data were evaluated using DDSolver conducted by (1) Statistical parameters: R2adjusted, AIC, MSC; (2) Visual goodness of fit (GOF). The results showed that aspirin floating tablets release kinetics followed the Korsmeyer-Peppas model. Aspirin release occurs through the mechanism of anomalous transport which combines Fickian diffusion and polymer relaxation.Key words: aspirin floating tablet, DDSolver, modeling of drug releaseen-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherFaculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesiaen-US
dc.relationhttp://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/782/652
dc.rightsCopyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY0
dc.rightshttp://creativecommons.org/licenses/by-sa/4.00
dc.sourceIndonesian Journal of Pharmacy; Vol 26 No 2, 2015; 94en-US
dc.source2338-9486
dc.source2338-9427
dc.titleIN VITRO RELEASE MODELING OF ASPIRIN FLOATING TABLETS USING DDSOLVERen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Articleen-US


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