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      Ibuprofen salt production and its application in tablet dosage form

      Date
      2009
      Author
      Hadisoewignyo, Lannie; Faculty of Pharmacy Unika Widya Mandala Surabaya Jl. Dinoyo 42-44 Surabaya-60265, Phone: 031-70007576
      Fudholi, Achmad; Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta
      Muchalal, M.; Faculty of Mathematics and Natural Sciences Universitas Gadjah Mada Yogyakarta
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      Abstract
      Ibuprofen is an anti-inflammatory drug and is practically insoluble in water. The low melting point and the poor flowability of ibuprofen can lead to process difficulty in tablets production. The purpose of this research was to make the sodium salt form of ibuprofen which has better solubility in water.Sodium ibuprofen salt was prepared by reacting the ibuprofen and sodium hydroxide, then characterized using TG/DTA, DSC, spectrophotometer UV-VIS, spectrophotometer IR, X-ray diffraction, and SEM. Tablets were prepared by wet granulation method.The characterization result showed that sodium ibuprofen result of the synthesis was dehydrate form with melting point of 199.9 °C. Granules of sodium ibuprofen result of the synthesis had better flowability and bigger density than ibuprofen granules. The physical characterization of the tablet showed that the formula of sodium ibuprofen resulted from the. Sodium ibuprofen showed the higher release rate than ibuprofen so can give quicker onset of action.Key words: sodium ibuprofen, ibuprofen, dissolution.
      URI
      http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/505/383 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/505
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      • Indonesia Journal of Pharmacy [413]

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      Copyright © Badan Litbangkes - Kementerian Kesehatan RI
      Jl. Percetakan Negara no.29, Jakarta Pusat 10560, Indonesia
      All rights reserved. 2019
      Contact Us | Send Feedback