| dc.contributor | | en-US |
| dc.creator | Adikwu, Elias; Department of Pharmacology, Faculty of Basic Medical Sciences, University of Port Harcourt, Choba, Rivers State Nigeria | |
| dc.creator | Apiakise, Williams; Department of Community Health Sciences, College of Health Technology, Otuogidi, Bayelsa State, Nigeria | |
| dc.date | 2016-12-23 | |
| dc.date.accessioned | 2019-10-29T03:15:05Z | |
| dc.date.available | 2019-10-29T03:15:05Z | |
| dc.identifier | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1096 | |
| dc.identifier | 10.14499/indonesianjpharm27iss4pp211 | |
| dc.identifier.uri | http://r2kn.litbang.kemkes.go.id:8080/xmlui/handle/123456789/25199 | |
| dc.description | Background and Objectives: Oxidative stress has been implicated in xenobiotic-induced hepatorenal toxicity. This research was designed to investigate the effects of vitamins C and E on the baseline and tenofovir/nevirapine-induced liver and kidney levels of superoxide dismutase (SOD), glutathione (GSH), catalase (CAT) and malondialdehyde (MDA) in male albino rats. Materials and Methods: Forty five male albino rats were used for this study. The rats were divided into groups A – I of 5 rats each. Group A (placebo control) and group B (solvent control) were orally treated with water and arachis oil respectively. Groups C – F were orally treated with vitamins C, E, vitamins C and E, and tenofovir/nevirapine respectively. Groups G– I were pretreated with vitamins C, E and vitamins C and E prior to treatment with tenofovir/nevirapine respectively. Rats were sacrificed after treatment for 30 days; liver and kidneys were collected and evaluated for the above parameters. Results: Significant (p<0.05) increases in the baseline levels of liver and kidney SOD, GSH, and CAT with decreases in MDA levels were obtained in vitamins C and E treated rats when compared to control. On the contrary, treatment with tenofovir/nevirapine significantly (p<0.05) decreased liver and kidney SOD, GSH, and CAT levels with increases in MDA levels when compared to control. However, all tenofovir/nevirapine -induced alterations were abrogated in rats pretreated vitamins C and E. Abrogation was most pronounced in rats pretreated with combined doses of vitamins C and E. Conclusion: Observations in the present study could be attributed to the inhibitory effects of vitamins C and E on the oxidative activity of tenofovir/nevirapine in the liver and kidney of treated rats. | en-US |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia | en-US |
| dc.relation | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1096/795 | |
| dc.rights | Copyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY | 0 |
| dc.rights | http://creativecommons.org/licenses/by-sa/4.0 | 0 |
| dc.source | Indonesian Journal of Pharmacy; Vol 27 No 4, 2016; 211 | en-US |
| dc.source | 2338-9486 | |
| dc.source | 2338-9427 | |
| dc.subject | tenofovir; nevirapine; liver; kidney; oxidative stress; antioxidants; rats | en-US |
| dc.title | Ameliorative effects of vitamins C and E on tenofovir/nevirapine-induced hepatorenal oxidative stress in albino rats | en-US |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | Peer-reviewed Article | en-US |
