Show simple item record

dc.contributoren-US
dc.creatorAdikwu, Elias; Department of Pharmacology, Faculty of Basic Medical Sciences, University of Port Harcourt, Choba, Rivers State Nigeria
dc.creatorApiakise, Williams; Department of Community Health Sciences, College of Health Technology, Otuogidi, Bayelsa State, Nigeria
dc.date2016-12-23
dc.date.accessioned2019-10-29T03:15:05Z
dc.date.available2019-10-29T03:15:05Z
dc.identifierhttp://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1096
dc.identifier10.14499/indonesianjpharm27iss4pp211
dc.identifier.urihttp://r2kn.litbang.kemkes.go.id:8080/xmlui/handle/123456789/25199
dc.descriptionBackground and Objectives: Oxidative stress has been implicated in xenobiotic-induced hepatorenal toxicity. This research was designed to investigate the effects of vitamins C and E on the baseline and tenofovir/nevirapine-induced liver and kidney levels of superoxide dismutase (SOD), glutathione (GSH), catalase (CAT) and malondialdehyde (MDA) in male albino rats. Materials and Methods: Forty five male albino rats were used for this study. The rats were divided into groups A – I of 5 rats each.   Group A (placebo control) and group B (solvent control) were orally treated with water and arachis oil respectively.  Groups C – F were orally treated with vitamins C, E, vitamins C and E, and tenofovir/nevirapine respectively. Groups G– I were pretreated with vitamins C, E and vitamins C and E prior to treatment with tenofovir/nevirapine respectively. Rats were sacrificed after treatment for 30 days; liver and kidneys were collected and evaluated for the above parameters. Results: Significant (p<0.05) increases in the baseline levels of liver and kidney SOD, GSH, and CAT with decreases in MDA levels were obtained in vitamins C and E treated rats when compared to control. On the contrary, treatment with tenofovir/nevirapine significantly (p<0.05) decreased liver and kidney SOD, GSH, and CAT levels with increases in MDA levels when compared to control. However, all tenofovir/nevirapine -induced alterations were abrogated in rats pretreated vitamins C and E. Abrogation was most pronounced in rats pretreated with combined doses of vitamins C and E. Conclusion: Observations in the present study could be attributed to the inhibitory effects of vitamins C and E on the oxidative activity of tenofovir/nevirapine in the liver and kidney of treated rats.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherFaculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesiaen-US
dc.relationhttp://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1096/795
dc.rightsCopyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY0
dc.rightshttp://creativecommons.org/licenses/by-sa/4.00
dc.sourceIndonesian Journal of Pharmacy; Vol 27 No 4, 2016; 211en-US
dc.source2338-9486
dc.source2338-9427
dc.subjecttenofovir; nevirapine; liver; kidney; oxidative stress; antioxidants; ratsen-US
dc.titleAmeliorative effects of vitamins C and E on tenofovir/nevirapine-induced hepatorenal oxidative stress in albino ratsen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Articleen-US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record