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dc.contributoren-US
dc.creatorHendradi, Esti; Department of Pharmaceutics, Faculty of Pharmacy Airlangga University. Jl. Dharmawangsa No.4-6, Airlangga, Gubeng, Kota SBY, Jawa Timur 60286
dc.creatorRosita, Noorma; Department of Pharmaceutics, Faculty of Pharmacy Airlangga University. Jl. Dharmawangsa No.4-6, Airlangga, Gubeng, Kota SBY, Jawa Timur 60286
dc.creatorRahmadhanniar, Erwinda; Department of Pharmaceutics, Faculty of Pharmacy Airlangga University. Jl. Dharmawangsa No.4-6, Airlangga, Gubeng, Kota SBY, Jawa Timur 60286
dc.date2017-10-31
dc.date.accessioned2019-10-29T03:15:08Z
dc.date.available2019-10-29T03:15:08Z
dc.identifierhttp://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1309
dc.identifier10.14499/indonesianjpharm28iss4pp198
dc.identifier.urihttp://r2kn.litbang.kemkes.go.id:8080/xmlui/handle/123456789/25207
dc.descriptionThe aim of this study was to determine the effect of lipid ratio of stearic acid and oleic acid on the physical characteristics as well as the entrapment efficiency of diethylammonium diclofenac with Nanostructure Lipid Carrier (NLC) system. Diethylammonium diclofenac (DETA) is Non-Steroid Anti-Inflamatory Drugs (NSAIDs) that has been widely used in the treatment of osteoarthritis and rheumatoid arthritis. In the formulation of NLC-DETA, three different lipid ratios were used, which the ratio of  stearic acid:oleic acid were 60:40, 70:30, and 80:20, respectively. In this NLC system, DETA served as the active drug, stearic acid as solid lipid, oleic acid as liquid lipid, and Tween 80 as surfactant components. NLC were characterized for organoleptic characteristics, pH, viscosity, particle morphology, particle size and polydispersity index (PI), profiles of Fourier Transform Infra-Red (FTIR) and Differential Thermal Analysis (DTA), and drug entrapment efficiency. The particle shape and morphology were determined by Transmission Electron Microscopy (TEM). The results  showed that the different ratios of oleic acid lipids and stearic acid had no significant effects on the viscosity and entrapment efficiency of NLC-DETA. On the other hand, it affected the pH of all formulas, which were significantly different. Increasing the amount of liquid lipid in the formulations reduced the size of NLC-DETA particles. en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherFaculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesiaen-US
dc.relationhttp://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1309/852
dc.rightsCopyright (c) 2018 INDONESIAN JOURNAL OF PHARMACY0
dc.rightshttp://creativecommons.org/licenses/by-sa/4.00
dc.sourceIndonesian Journal of Pharmacy; Vol 28 No 4, 2017; 198en-US
dc.source2338-9486
dc.source2338-9427
dc.subjectDETA, NLC, physicochemical characterization, entrapment efficiencyen-US
dc.titleEffect of Lipid Ratio of Stearic Acid and Oleic Acid on Characteristics of Nanostructure Lipid Carrier (NLC) System of Diethylammonium Diclofenacen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Articleen-US


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