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      Determination of Sitagliptin Levels in Rats Serum by HPLC and its Pharmacokinetic Investigation in Existence of Sucralose

      Date
      2018
      Author
      Dayyih, Wael Abu; Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy and Medical Sciences, University of Petra, Queen Alia International Road, Amman - Jordan 11196, Jordan
      Hamad, Mohammed; Department of Basic Sciences, Collage of Sciences and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Jeddah 21423, Saudi Arabia
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      Abstract
      It is an interest of the current work to develop a simple, valid and rapid chromatographic method for the quantification of sitagliptin in rats' serum. Accordingly, the pharmacokinetic parameters of sitagliptin was investigated for any possible interaction between sitagliptin and sucralose. The developed HPLC method was validated for sitagliptin determination in rat’s serum. Results indicated an accomplished overall intra-day precision and accuracy values of 0.139-4.028 (CV%) and 99.48-107.12% respectively. On the other hand, inter-day precision and accuracy results recorded values of 0.150-2.810 (CV%) and 99.90-116.00% respectively. Moreover, the coefficient of correlation was determined at a value of 0.99950 with reasonable sensitivity and selectivity. Effect of sucralose showed strong significant correlation on sitagliptin serum profile. The precise, accurate, linear, sensitive and selective HPLC method will be elaborated in the context of the current work with emphasis on sucralose negative effect on sitagliptin level in rat’s serum. Such finding is a guidance for physicians to reconsider the use of such sweeteners for diabetic patients
      URI
      http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1383/873 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1383
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      • Indonesia Journal of Pharmacy [413]

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      Copyright © Badan Litbangkes - Kementerian Kesehatan RI
      Jl. Percetakan Negara no.29, Jakarta Pusat 10560, Indonesia
      All rights reserved. 2019
      Contact Us | Send Feedback