View Item 
      •   R2KN Home
      • Perguruan Tinggi
      • Universitas Gajah Mada
      • Indonesia Journal of Pharmacy
      • View Item
      •   R2KN Home
      • Perguruan Tinggi
      • Universitas Gajah Mada
      • Indonesia Journal of Pharmacy
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      FAST DISSOLVING TABLETS OF PIMOZIDE: DESIGN, OPTIMIZATION AND INVITRO CHARACTERIZATION

      Date
      2015
      Author
      Kamisetti, Raja Rajeswari; 1Vishnu Institute of Pharmaceutical Education and Research, (Affiliated to Jawaharlal Nehru Tech. University, Hyderabad), Narsapur, Medak, Hyderabad 502 313.
      Mekala, Moses; Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad. 500 014.
      Muvvala, Sudhakar; Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad. 500 014.
      Penmatsa, Durga Bhavani; Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad. 500 014.
      Metadata
      Show full item record
      Abstract
      As precision of dosing and patient compliance become an important prerequisite for a long-term treatment of Tourette’s syndrome there is a need to develop formulation for this drug, which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling and patient’s acceptability. The present work was undertaken with a view to develop a fast dissolving tablets of Pimozide  using Kyron T-314 as super-disintegrant along with Avicel PH 102 as diluent by response surface method using direct compression. Drug-excipient compatibility studies were confirmed by FTIR Spectroscopy. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content and invitro dissolution. Based on evaluating parameters, formulation prepared by using 4.5% Kyron T-314 with 11.5% Avicel PH-102 was selected as optimized formulation and Formulation (F3) had disintegration time of 7.63±0.25s. and percentage cumulative drug release of   81.60 after 10min. The formulations were further studied and confirmed for their stability. Hence it was concluded that direct compression using Kyron T-314 superdisintegrant and Avicel PH 102 was simple and economic technique which can be used for formulation of fast dissolving tablets of Pimozide.Key word: Pimozide, Tourette’s syndrome, fast dissolving tablets, Kyron T 314, direct compression 
      URI
      http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/785/655 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/785
      Collections
      • Indonesia Journal of Pharmacy [413]

      Copyright © Badan Litbangkes - Kementerian Kesehatan RI
      Jl. Percetakan Negara no.29, Jakarta Pusat 10560, Indonesia
      All rights reserved. 2019
      Contact Us | Send Feedback
        

       

      Browse

      All of R2KNCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

      My Account

      LoginRegister

      Copyright © Badan Litbangkes - Kementerian Kesehatan RI
      Jl. Percetakan Negara no.29, Jakarta Pusat 10560, Indonesia
      All rights reserved. 2019
      Contact Us | Send Feedback