Show simple item record

dc.contributoren-US
dc.creatorKamisetti, Raja Rajeswari; 1Vishnu Institute of Pharmaceutical Education and Research, (Affiliated to Jawaharlal Nehru Tech. University, Hyderabad), Narsapur, Medak, Hyderabad 502 313.
dc.creatorMekala, Moses; Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad. 500 014.
dc.creatorMuvvala, Sudhakar; Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad. 500 014.
dc.creatorPenmatsa, Durga Bhavani; Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad. 500 014.
dc.date2015-04-04
dc.date.accessioned2019-10-29T03:15:25Z
dc.date.available2019-10-29T03:15:25Z
dc.identifierhttp://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/785
dc.identifier10.14499/indonesianjpharm26iss2pp114
dc.identifier.urihttp://r2kn.litbang.kemkes.go.id:8080/xmlui/handle/123456789/25243
dc.descriptionAs precision of dosing and patient compliance become an important prerequisite for a long-term treatment of Tourette’s syndrome there is a need to develop formulation for this drug, which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling and patient’s acceptability. The present work was undertaken with a view to develop a fast dissolving tablets of Pimozide  using Kyron T-314 as super-disintegrant along with Avicel PH 102 as diluent by response surface method using direct compression. Drug-excipient compatibility studies were confirmed by FTIR Spectroscopy. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content and invitro dissolution. Based on evaluating parameters, formulation prepared by using 4.5% Kyron T-314 with 11.5% Avicel PH-102 was selected as optimized formulation and Formulation (F3) had disintegration time of 7.63±0.25s. and percentage cumulative drug release of   81.60 after 10min. The formulations were further studied and confirmed for their stability. Hence it was concluded that direct compression using Kyron T-314 superdisintegrant and Avicel PH 102 was simple and economic technique which can be used for formulation of fast dissolving tablets of Pimozide.Key word: Pimozide, Tourette’s syndrome, fast dissolving tablets, Kyron T 314, direct compression en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherFaculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesiaen-US
dc.relationhttp://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/785/655
dc.rightsCopyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY0
dc.rightshttp://creativecommons.org/licenses/by-sa/4.00
dc.sourceIndonesian Journal of Pharmacy; Vol 26 No 2, 2015; 114en-US
dc.source2338-9486
dc.source2338-9427
dc.titleFAST DISSOLVING TABLETS OF PIMOZIDE: DESIGN, OPTIMIZATION AND INVITRO CHARACTERIZATIONen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Articleen-US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record