View Item 
      •   R2KN Home
      • Perguruan Tinggi
      • Universitas Gajah Mada
      • Indonesia Journal of Pharmacy
      • View Item
      •   R2KN Home
      • Perguruan Tinggi
      • Universitas Gajah Mada
      • Indonesia Journal of Pharmacy
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Liver and kidney histopathological test of mice received Pauh Kijang (Irvingia malayana Oliv ex A. Benn) extract

      Date
      2008
      Author
      ., Praptiwi; Biology Center of Literatur, LIPI Herbarium Bogoriense Cibinong Science Center (CSC) Jl. Raya Jakarta-Bogor Km. 46 - CIBINONG, 16911
      Agungpriyono, Dewi Ratih; Faculty of Veterinary, Bogor Agricultural Institute Herbarium Bogoriense Cibinong Science Center (CSC) Jl. Raya Jakarta-Bogor Km. 46 - CIBINONG, 16911
      Rahayu, Esti; Faculty of Veterinary, Bogor Agricultural Institute Herbarium Bogoriense Cibinong Science Center (CSC) Jl. Raya Jakarta-Bogor Km. 46 - CIBINONG, 16911
      Metadata
      Show full item record
      Abstract
      The background of this study was to determine the safety of pauh kijang extract which is orally given to mice while the aim of the study was to evaluate the liver and kidney histopathological changes after receiving various dose of the extract mango (Irvingia malayana Oliv. Exe Benth.) ethanol extract. There were five group of treatments in this study : mice received extract with the concentration of (I) 1000mg /kg BW, (II)100 mg/kg BW, (III) 10 mg/kg BW, (IV) 1 mg/kg BW, and (V) received carboxy methyl cellulose-sodium (CMC-Na) as negative control. Each treatment consisted of five mice. After seven days of treatment, mice were sacrified. The liver and kidney were sampled and processed to prepare histopathology slides. The histopathology parameters were examined by counting the degeneration and necrotic cells of hepatocytes and renal epithelial tubule. The lesion of glomerulus such as atrophy and protein sedimentation were also observed. The result also showed that extract concentration of > 10 mg/kg BW result in damaging liver cells significantly, while kidney cell damage occurred significantly in the exposure of extract > 1 mg/kg BW.Key words : Irvingia malayana, liver, kidney
      URI
      http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/314/195 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/314
      Collections
      • Indonesia Journal of Pharmacy [413]

      Related items

      Showing items related by title, author, creator and subject.

      • Hubungan Rokok Terhadap Intelegensi Siswa SMK I Cibinong Di Kabupaten Bogor 

        Nurkhotimah, Enung
      • HUBUNGAN UMUR DAN KADAR TROMBOSIT DENGAN DERAJAT DHF PADA ANAK DI RSUD CIBINONG KABUPATEN BOGOR PADA TAHUN 2010 

        ARUM PUSPITA SARI
      • Gambaran Identitas Diri dan Perilaku Imitasi Pada Remaja di SMA Negeri 1 Cibinong Kabupaten Bogor Tahun 2017 

        Penulis : Dina Betris Panjaitan Pembimbing : Tantri Widyarti Utami, M. Kep., Sp. Jiwa Penguji 1 : Drs. I Nengah Mustika, M.Kes Penguji 2 : Dra. Yunani Sri Astuti, M. Kes

      Copyright © Badan Litbangkes - Kementerian Kesehatan RI
      Jl. Percetakan Negara no.29, Jakarta Pusat 10560, Indonesia
      All rights reserved. 2019
      Contact Us | Send Feedback
        

       

      Browse

      All of R2KNCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

      My Account

      LoginRegister

      Copyright © Badan Litbangkes - Kementerian Kesehatan RI
      Jl. Percetakan Negara no.29, Jakarta Pusat 10560, Indonesia
      All rights reserved. 2019
      Contact Us | Send Feedback