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dc.contributoren-US
dc.creator., Praptiwi; Biology Center of Literatur, LIPI Herbarium Bogoriense Cibinong Science Center (CSC) Jl. Raya Jakarta-Bogor Km. 46 - CIBINONG, 16911
dc.creatorAgungpriyono, Dewi Ratih; Faculty of Veterinary, Bogor Agricultural Institute Herbarium Bogoriense Cibinong Science Center (CSC) Jl. Raya Jakarta-Bogor Km. 46 - CIBINONG, 16911
dc.creatorRahayu, Esti; Faculty of Veterinary, Bogor Agricultural Institute Herbarium Bogoriense Cibinong Science Center (CSC) Jl. Raya Jakarta-Bogor Km. 46 - CIBINONG, 16911
dc.date2008-10-01
dc.date.accessioned2019-10-29T03:15:36Z
dc.date.available2019-10-29T03:15:36Z
dc.identifierhttp://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/314
dc.identifier10.14499/indonesianjpharm0iss0pp172-177
dc.identifier.urihttp://r2kn.litbang.kemkes.go.id:8080/xmlui/handle/123456789/25267
dc.descriptionThe background of this study was to determine the safety of pauh kijang extract which is orally given to mice while the aim of the study was to evaluate the liver and kidney histopathological changes after receiving various dose of the extract mango (Irvingia malayana Oliv. Exe Benth.) ethanol extract. There were five group of treatments in this study : mice received extract with the concentration of (I) 1000mg /kg BW, (II)100 mg/kg BW, (III) 10 mg/kg BW, (IV) 1 mg/kg BW, and (V) received carboxy methyl cellulose-sodium (CMC-Na) as negative control. Each treatment consisted of five mice. After seven days of treatment, mice were sacrified. The liver and kidney were sampled and processed to prepare histopathology slides. The histopathology parameters were examined by counting the degeneration and necrotic cells of hepatocytes and renal epithelial tubule. The lesion of glomerulus such as atrophy and protein sedimentation were also observed. The result also showed that extract concentration of > 10 mg/kg BW result in damaging liver cells significantly, while kidney cell damage occurred significantly in the exposure of extract > 1 mg/kg BW.Key words : Irvingia malayana, liver, kidneyen-US
dc.format
dc.languageeng
dc.publisherFaculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesiaen-US
dc.relationhttp://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/314/195
dc.rightsCopyright (c) 2017 INDONESIAN JOURNAL OF PHARMACY0
dc.rightshttp://creativecommons.org/licenses/by-sa/4.00
dc.sourceIndonesian Journal of Pharmacy; Vol 19 No 4, 2008; 172-177en-US
dc.source2338-9486
dc.source2338-9427
dc.titleLiver and kidney histopathological test of mice received Pauh Kijang (Irvingia malayana Oliv ex A. Benn) extracten-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Articleen-US


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