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      Hesperidin increase cytotoxic effect of doxorubicin in MCF-7 cells

      Date
      2016
      Author
      Hermawan, Adam; Cancer Chemoprevention Research Center Fakultas Farmasi, Universitas Gadjah Mada
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      Abstract
      Hesperidin, a flavonoid, shows strong cytotoxic effect in several cancer cell lines. The aim of this research was to investigate cytotoxic activities of hesperidin alone and in combination with doxorubicin. Cell viability assay of hesperidin, doxorubicin, and combination treatments were carried out by using MTT assay. Apoptosis assay was done using double staining method using Ethidium Bromide-Acridine Orange. Hesperidin did not show cytotoxic effect          but doxorubicin showed cytotoxic effect with IC50 467 nM. Hesperidin (5, 50 and  100 µM) increased cytotoxic effect of doxorubicin compared with doxorubicin alone. The strongest cytotoxic activity was showed by the combination of 200 nM doxorubicin and 100 µM hesperidin. Combination treatment of doxorubicin 200 nM and hesperidin 100 µM induced apoptosis in MCF-7 cells. Hesperidin is potentially to be developed as co-chemotherapeutic agent for breast cancer, while molecular mechanism need to be explored.  Key words: Hesperidin, doxorubicin, synergism, MCF-7, apoptosis
      URI
      http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/downloadSuppFile/92/1 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/92
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      • Indonesia Journal of Pharmacy [413]

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      Copyright © Badan Litbangkes - Kementerian Kesehatan RI
      Jl. Percetakan Negara no.29, Jakarta Pusat 10560, Indonesia
      All rights reserved. 2019
      Contact Us | Send Feedback