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      A REVIEW ON SUPRAMOLECULAR CHEMISTRY IN DRUG DESIGN AND FORMULATION RESEARCH

      Date
      2013
      Author
      Vepuri, Suresh B; Pharmaceutical Chemistry GITAM Institute of Pharmacy, GITAM University, Vishakapatnam- 530045, AP, India
      Anbazhagan, S.; Karuna College of Pharmacy, Thirumittacode, Palakad-679533, Kerala, India
      Divya, D.; Pharmaceutical Chemistry GITAM Institute of Pharmacy, GITAM University, Vishakapatnam- 530045, AP, India
      Padmini, D.; Pharmaceutical Chemistry GITAM Institute of Pharmacy, GITAM University, Vishakapatnam- 530045, AP, India
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      Abstract
      Supramolecular chemistry, other way called as intermolecular chemistry disclose the relationship of molecules with environment. It exploits while exposing the physicochemical phenomina that happens when two like or unlike molecules/ions/systems contact each other. Drug action involve the target recognition process and response triggered by the intermolecular complex of drug and target. Drug design therefore require in depth study of intermolecular forces that exist between drug and target. Formulation of the drug or Active Pharmaceutical Ingredient (API) is also regulated by these forces. Compatibility and incompatibility in formulations are nothing but of the effect of the intermolecular forces on physical behavior of systems. Therefore review of intermolecular chemistry in general and its role particularly in pharmaceutical research is presented here for the benefit of the students and research scholars who aspire to work on interdisciplinary projects in the field of pharmacy. Key words: intermolecular forces, hydrogen bond, drug design, active pharmaceutical ingredient (API), crystal.
      URI
      http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/583/458 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/583
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      • Indonesia Journal of Pharmacy [413]

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      Copyright © Badan Litbangkes - Kementerian Kesehatan RI
      Jl. Percetakan Negara no.29, Jakarta Pusat 10560, Indonesia
      All rights reserved. 2019
      Contact Us | Send Feedback