View Item 
      •   R2KN Home
      • Perguruan Tinggi
      • Universitas Gajah Mada
      • Indonesia Journal of Pharmacy
      • View Item
      •   R2KN Home
      • Perguruan Tinggi
      • Universitas Gajah Mada
      • Indonesia Journal of Pharmacy
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Cytotoxicity of Tetrahydropentagamavunon-0 (THPGV)-0 and Tetrahydropentagamavunon-1 (THPGV-1) in Several Cancer Cell Lines

      Date
      2018
      Author
      Ikawati, Muthi; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia
      Purwanto, Heri; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia
      Imaniyyati, Niar Nurul; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia
      Afifah, Anis; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia
      Sagiyo, Marrita Langgeng; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia
      Yohanes, Jasson; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia
      Sismindari, Sismindari; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia
      Ritmaleni, Ritmaleni; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia
      Metadata
      Show full item record
      Abstract
      Tetrahydropentagamavunon-0 (THPGV-0) and Tetrahydro-pentagamavunon-1 (THPGV-1), are analogs of a curcumin metabolite, tetrahydrocurcumin, and a derivate of Pentagama-vunon-0 (PGV-0) and Pentagamavunon-1 (PGV-1), respectively.  THPGV-0 and THPGV-1 have been successfully synthesized and are investigated for their anticancer potency.  Cytotoxic assays were performed toward several cancer cell lines to determine values of the IC50 against those cell lines. Assessing cytotoxicity in Vero normal cell line showed the selectivity of those compound.  THPGV-1 showed highest cytotoxic activity in lymphoma Raji cells, a suspension cell line, with an IC50 of 180mM.  Both THPGV-0 and THPGV-1 showed similar potencies in T47D breast cancer cell line with IC50 values of 250-270mM.  Regardless their high selectivity, however, cytotoxic activities of THPGV-0 and THPGV-1 were lower compared to PGV-0 and PGV-1 in HeLa cervical, T47D breast, and WiDr colon cancer cell lines.  Further study using different types of cancer cell lines and confirmation of cell viability by another assays and apoptosis detection may give more benefit. 
      URI
      http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1424/882 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1424
      Collections
      • Indonesia Journal of Pharmacy [413]

      Related items

      Showing items related by title, author, creator and subject.

      • Snake beans (Vigna sinensis (L) Savi ex Hassk) extract increases breast epithelial cells proliferation 

        Meiyanto, Edy; Cancer Chemoprevention Research Center (CCRC), Faculty of Pharmacy, Universitas Gadjah Mada Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara Yogyakarta, 55281. Phone 0274-543120; Handayani, Sri; Cancer Chemoprevention Research Center (CCRC), Faculty of Pharmacy, Universitas Gadjah Mada Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara Yogyakarta, 55281. Phone 0274-543120; Jenie, Riris Istighfari; Cancer Chemoprevention Research Center (CCRC), Faculty of Pharmacy, Universitas Gadjah Mada Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara Yogyakarta, 55281. Phone 0274-543120
      • HEPATOPROTECTIVE EFFECT OF GAMAVUTON-0 AGAINST D˗GALACTOSAMINE/LIPOPOLYSACCHARIDE-INDUCED FULMINANT HEPATIC FAILURE 

        Nurrochmad, Arief; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara Yogyakarta 55281, Indonesia; Sari, Ika Puspita; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara Yogyakarta 55281, Indonesia; Murwanti, Retno; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara Yogyakarta 55281, Indonesia; ., Sardjiman; Curcumin Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Yogyakarta 55281, Indonesia.; Candraningrum, Triana; Curcumin Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Yogyakarta 55281, Indonesia.; Afritasari, Dyah; Curcumin Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Yogyakarta 55281, Indonesia.; Martina, Devina; Curcumin Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Yogyakarta 55281, Indonesia.; Siahaan, Iren Wati; Curcumin Research Center, Faculty of Pharmacy, Universitas Gadjah Mada Yogyakarta 55281, Indonesia.
      • INCREASING SENSITIVITY OF MCF-7/DOX CELLS TOWARDS DOXORUBICIN BY HESPERETIN THROUGH SUPPRESSION OF P-GLYCOPROTEIN EXPRESSION 

        Sarmoko, .; Depertment of Pharmacy, Faculty of Medicine and Health Sciences, Jenderal Soedirman University, Jl. Dr.Gumbreg, Medical Street 53122. Purwokerto,Indonesia; Pamungkas P, Dyaningtyas Dewi; 1Cancer Chemoprevention Research Center, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta Sekip Utara 55281, Indonesia; Susidarti, Ratna Asmah; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta Sekip Utara 55281, Indonesia; Nugroho, Agung Endro; 1Cancer Chemoprevention Research Center, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta Sekip Utara 55281, Indonesia; Meiyanto, Edy; Cancer Chemoprevention Research Center, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta Sekip Utara 55281, Indonesia

      Copyright © Badan Litbangkes - Kementerian Kesehatan RI
      Jl. Percetakan Negara no.29, Jakarta Pusat 10560, Indonesia
      All rights reserved. 2019
      Contact Us | Send Feedback
        

       

      Browse

      All of R2KNCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

      My Account

      LoginRegister

      Copyright © Badan Litbangkes - Kementerian Kesehatan RI
      Jl. Percetakan Negara no.29, Jakarta Pusat 10560, Indonesia
      All rights reserved. 2019
      Contact Us | Send Feedback