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dc.contributoren-US
dc.creatorRajamani, Sumathi; assistant professor
dc.creatorSengodan, Tamizharasi; assistant professor
dc.creatorThangavelu, Sivakumar; professor
dc.creatorShanmukhan, Nikhitha K
dc.creatorRadhakrishnan, Arun; Lecturer Dep. of pharmaceutics, JSS College of pharmcy, Ooty, JSS Academy of higher education and research
dc.date2019-09-24
dc.date.accessioned2019-10-29T03:17:08Z
dc.date.available2019-10-29T03:17:08Z
dc.identifierhttp://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1514
dc.identifier10.14499/indonesianjpharm30iss3pp225
dc.identifier.urihttp://r2kn.litbang.kemkes.go.id:8080/xmlui/handle/123456789/25533
dc.descriptionNaringenin, (NAR) from Citrus grandis(L.) Osbeck, family Rutaceae, exhibit extensive pharmacological action, lacks significance in application due to low aqueous solubility approximately  0.214 mg/ml, which results in low bioavailability of 5.8%. Nanosuspension of NAR (NARNS) was prepared in our previous studies using high pressure homogenization adding various polymers. All these formulations were characterized and as a continuation of our work formulations was further evaluated for their anti-inflammatory activity by in-vitro and in-vivo methods. Denaturation of protein method and membrane stabilization methods were chosen for in-vitro evaluation. In-vivo studies performed were acute inflammatory studies (carrageenan-induced paw oedema) and chronic inflammatory studies (cotton pellet granuloma) on Wistar albino rats. The studies demonstrated that the NAR and NARNS at a dose of 50 mg/kg P.O. have a potent activity compared to the standard drug diclofenac.  The percentage protection against inflammation exhibited by NARNS was highly significant compared to NAR.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherFaculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesiaen-US
dc.relationhttp://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1514/919
dc.rightsCopyright (c) 2019 Indonesian Journal of Pharmacy0
dc.rightshttp://creativecommons.org/licenses/by-sa/4.00
dc.sourceIndonesian Journal of Pharmacy; Vol 30 No 3, 2019; 225en-US
dc.source2338-9486
dc.source2338-9427
dc.subjectCarrageenan, oxidative stress, anti-inflammatory, Naringeninen-US
dc.titleNaringenin-Loaded TPGS Polymeric Nanosuspension: In-Vitro and In-Vivo Anti-Inflammatory Activityen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Articleen-US


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