Health about reproduction extremely needed by teenagers started in puberty. However, reproduction health education in Indonesia is not common and considered taboo to be given to the teenagers. Even though health education is needed to prevent teenagers problem occurrence, as effect of untrue perception about health reproduction.The purpose of this reasearh is finding out the influence of health education about reproduction against change of teenage girls perception. This research is used One Group Pretest Postest Design Method. It is research design which is on pretest before given by treatment and posttest after given by treatment. The taken population is 403 teenage girls from working area of Puskesmas Warungasem. The researcher use purposive sampling.The data collection is done directly by using questioner. The data analysis result shows that, thore is differences of perception degree between before and after giving health education which shows enhancement teenage girls perception. This can be spen from the result of teenage girl average score before given the health education as 17,28 and after given the health education increase 21,40. From the T result, it is obtained that teenage girls who have positive perception reach 42 %, after they are given health education increase to 59.2 % and statistic pair t result p value is 0,00 < a (0,05).This research is expected that the teenagers can choose the conducive environment which easily getting the health reproduction information. Health workers are also necessary to socialize more intensively about health reproduction to the teenage girls.