Background: Typhoid fever is an intestinal infection caused by salmonella typhi or salmonella paratyphi A, B, C. One of the symptoms of typhoid fever is hyperthermia or elevated body temperature ? 38 0C. Hyperthermia if not managed properly can lead to dehydration until seizures.Objectives: Conducting nursing care of typhoid fever clients with hyperthermia nursing problems.Methods: The study design was descriptive by comparing two respondents with hyperthermia focus on typhoid fever.Results: From the two respondents' research for 3x24 hours the problem of hyperthermia was resolved in accordance with the objectives and the planned outcome criteria. Intervention with TTV observation every 4 hours, warm compress, plenty to drink, adequate rest, increase air circulation, wear a layer of clothes that absorbs sweat. Proven effective to lower the temperature of hyperthermia clients.Recommendations: Involving clients and families in handling hyperthermia clients is needed by nurses.