The installation of an endotracheal tube is one of the treatments for airway problems. No cough reflex that is effective in patients who lose consciousness can pose a risk of aspiration. Incorrect suction procedures can cause complications in patients. One of them is reducing oxygen saturation. The general objective of this case study is to explain airway management in patients who are attached to an endotracheal tube at the Emergency Unit of Tugurejo Hospital Semarang. The method used is a case study with the application of evidence-based practice and observation. In both patients taking action, they showed a decrease in saturation but not less than 95%. This refers to the administration of hyperoxygenation, regulation of pressure, and setting the duration of the suction procedure effective in maintaining oxygen saturation ? 95% in patients with endotracheal tubes.