Background: Hemodialysis is a therapy that functions to replace kidney function to excrete metabolic waste products and water in the blood through semi-permeable membranes or dializers. Kanulation is an intervention that enters the needle through the skin to the blood vessels (AV Shunt or Femoral) as a means to connect the vascular circulation with the hemodialysis machine during the hemodialysis process. Arterivenous stabbing causes pain sensation in patients. The pain felt by the patient during stabbing will differ in each patient depending on the pain threshold of each individual. Pain management in all spheres of the health profession is an important component especially in the field of nursing. Aim: To determine the effect of acupressure intervention at large intestinum point 4 (LI-4) on decreasing the scale of AV-Fistula cannulation pain.Method: this study uses a case study design. Samples: The study used two case respondents with AV Shunt vascular access. Pain scale data before and after the intervention were taken using a numeric rating scale (NRS) pain assessment instrument. Results: based on the results of the study, the average scale of pain before intervention was 4 and the average scale of pain after intervention was 2.5. Conclusion: From these results it can be concluded that the intervention of acupressure at the LI-4 point was influential in reducing the scale of AV-Fistula cannulation pain in hemodialysis patients. Recommendation: acupressure intervention at point LI-4 can be applied by nurses as a non-pharmacological pain management intervention to reduce AV-fistula cannulation pain in hemodialysis patients.