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dc.creatorPurnamayanti, Ni Made Dwi
dc.creatorWindu, Siti Candra
dc.creatorPoeranto, Sri
dc.date2018
dc.date.accessioned2019-12-01T23:27:08Z
dc.date.available2019-12-01T23:27:08Z
dc.identifierhttp://repository.poltekkes-denpasar.ac.id/3146/1/Effect%20of%20Nigella%20sativaEthanol%20Extract%20on%20the%20Nitric%20Oxide%20Content.pdf
dc.identifierPurnamayanti, Ni Made Dwi and Windu, Siti Candra and Poeranto, Sri (2018) Effect of Nigella sativa Ethanol Extract on the Nitric Oxide Content and Renal Arteriole Diameter of a Pre-eclampsia Mouse Model. The Eurasian Journal of Medicine, 50 (3). pp. 148-151.
dc.identifier.urihttp://r2kn.litbang.kemkes.go.id:8080/xmlui/handle/123456789/67618
dc.descriptionObjective: The aim of this study was to investigate the effect of Nigella sativa ethanol extract on nitric oxide (NO) levels and renal arteriole diameter of a pre-eclampsia mouse model. Materials and Methods: This experimental study was conducted using a post-test only control group design. Thirty BALB/c mice were divided into six groups: one negative control (normal pregnant mice), one positive control (pre-eclampsia model), and four groups of pre-eclampsia mice treated with varying doses of N. sativa (500 mg/kg body weight (BW)/day, 1000 mg/kg BW/day, 1500 mg/kg BW/day, and 2000 mg/kg BW/day). Ethanol extract of N. sativa was given for 5 days. Data were analyzed using analysis of variance. Results: We detected significant differences in NO levels between the pre-eclampsia mouse model and those given the ethanol extract. The latter had NO levels of 85.77±4.47 µM (500 mg/kg BW/day), 189.04±6.01 µM (1000 mg/kg BW/day), 226.56±2.13 µM (1500 mg/BW/day), and 207.98±4.74 µM (2000 mg/kg BW/day). The mean renal arteriole diameter showed significant differences among the treatment groups with N. sativa doses of 1000, 1500, and 2000 mg (15.15±2.21b μm, 16.35±2.52b μm, and 15.76±3.03b µm, respectively). Conclusion: N. sativa ethanol extract treatment increases NO levels and enlarges renal arteriole diameter of a pre-eclampsia mouse model in a dose-dependent manner. Keywords: Nitric oxide, Nigella sativa, pre-eclampsia, renal arteriole diameter
dc.formattext
dc.languageen
dc.publisherThe Atatürk University School of Medicine
dc.relationhttp://repository.poltekkes-denpasar.ac.id/3146/
dc.relationhttps://www.eajm.org/sayilar/210/buyuk/148-151.pdf
dc.relation10.5152/eurasianjmed.2018.17123
dc.subjectRG Gynecology and obstetrics
dc.titleEffect of Nigella sativa Ethanol Extract on the Nitric Oxide Content and Renal Arteriole Diameter of a Pre-eclampsia Mouse Model
dc.typeArticle
dc.typePeerReviewed


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