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dc.contributorid-ID
dc.creatorSiswantoro, Hadjar
dc.creatorHasugian, Armedy Ronny
dc.creatorAvrina, Rossa
dc.creatorRisniati, Yenni
dc.creatorTjitra, Emiliana
dc.date2012-07-16
dc.date.accessioned2019-12-13T03:31:24Z
dc.date.available2019-12-13T03:31:24Z
dc.identifierhttp://ejournal.litbang.depkes.go.id/index.php/MPK/article/view/95
dc.identifier10.22435/mpk.v21i3 Sept.95.
dc.identifier.urihttp://r2kn.litbang.kemkes.go.id:8080/handle/123456789/79787
dc.descriptionSince 2008, Dihydroartemisinin-Piperaquine (DHP) has been used as the first-line drug for treatment of falciparum malaria in Papua, which gradually will also be used in other endemic areas. The objective of the study was  to determine the safety and efficacy of DHP. Patients with uncomplicated malaria due to Plasmodium falciparum were enrolled and treated with supervised DHP (arterakin ®, no. batch 010 909) daily dose for three days. Patients were followed for 42 days. Patients during follow up did physical examination and checked for microscopic parasites, measurement of hemoglobin levels (day 0, 14, 28 and 42), making the blood spot PCR (day 0 and day relapse), pregnancy test for women of childbearing age (Day 0 and 28). 119 patients were enrolled in the study. Therapeutic efficacy of DHP by day 42 in ITT and PP population were 98.3% (95% CI: 94.1-99.5%) and 100% (95% CI: 96.9-100%). The means of parasite clearance and fever clearance were 1.0 day and 1.6 days, and clinical symptoms was reduced by over 50% by day-7 follow up. All patients with gametocytes on day 0, generally were cleared on day 28 . There were an increasing number of patients with recovery hemoglobin at day 14, 28 and 42: 61%, 78% and 84%. Adverse events were mild, ie cough (31%) and abdominal pain (10%). Dihydroartemisinin-piperaquine was safe and effective for the treatment of uncomplicated P. falciparum malaria. AbstrakSejak 2008, program telah menggunakan dihidroartemisinin-piperakuin (DHP) sebagai pilihan pertama pengobatan malaria falsiparum di Papua, yang secara bertahap juga akan digunakan di wilayah endemis lainnya. Tujuan penelitian ini adalah untuk menilai keamanan  dan efikasi obat DHP. Pasien malaria falsiparum tanpa komplikasi diikutkan dalam studi dan diobati DHP (arterakin ®, no. batch 010 909) dengan pengawasan minum obat dosis satu kali sehari selama tiga hari. Selanjutnya pasien dipantau selama 42 hari. Pasien selama kunjungan ulang dilakukan pemeriksaan fisik dan cek parasit mikroskopis, diukur kadar hemoglobin (hari 0, 14, 28 dan 42), dibuat spot darah PCR (hari 0 dan hari kambuh), tes kehamilan pada wanita usia subur. Sebanyak 119 pasien direkruit pada penelitian ini. Efikasi terapeutik obat DHP pada hari ke 42 per populasi ITT dan PP adalah 98.3% (95% CI: 94.1-99.5%) dan 100% (95% CI: 96.8-100%). Rerata bebas parasit dan bebas demam adalah 1.0 hari dan 1.6 hari, dan gejala klinis berkurang hingga di atas 50% pada hari ke-7 kunjungan ulang. Pasien dengan karier gametosit pada saat rekruitmen, umumnya pada hari ke-28 sudah bebas gametosit. Terdapat peningkatan jumlah pasien dengan perbaikan hemoglobin pada hari ke 14, 28 dan 42: 61%, 78% dan  84%.  Kejadian sampingan adalah ringan, yaitu batuk (31%) dan sakit perut (10%).Dihidroartemisinin-piperakuin adalah aman dan efektif pada pengobatan malaria falsiparum tanpa komplikasi.id-ID
dc.formatapplication/pdf
dc.languageid
dc.publisherBadan Penelitian dan Pengembangan Kesehatanen-US
dc.rightsThe Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Media Penelitian dan Pengembangan Kesehatan (Media of Health Research & Development) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development) as publisher of the journal.Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc. , will be allowed only with a written permission from Media Penelitian dan Pengembangan Kesehatan (Media of Health Research & Development) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development).Media Penelitian dan Pengembangan Kesehatan (Media of Health Research & Development) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development), the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal.
dc.sourceMedia Penelitian dan Pengembangan Kesehatan; Vol 21, No 3 Sept (2011)en-US
dc.sourceMedia Penelitian dan Pengembangan Kesehatan; Vol 21, No 3 Sept (2011)id-ID
dc.titleEFIKASI DAN KEAMANAN DIHIDROARTEMISININ-PIPERAKUIN (DHP) PADA PENDERITA MALARIA FALSIPARUM TANPA KOMPLIKASI DI KALIMANTAN DAN SULAWESIid-ID
dc.typePeer-reviewed Articleen-US


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