In the area of Hepatitis A outbreak, washing hand before handling food is very important, because most of the cases do not wash their hand before breakfast, lunch or dinner and they eat without spoon. This study is to find out relation between washing hand before handling food with clinical acute hepatitis cases in the area of Hepatitis A outbreak. This study used a case control design, analysing secondary data of Hepatitis A outbreak investigation from November 2001 to January 2002. The population is a the community which living in Calincing housing in Cogreg Village, Parungsub district of Bogor, aged between 15 to 55 years old. Sixty cases and 120 controls have been analysed. Result of this study found that there is a significant relation (p=0.000) between washing hand before handling food with clinical acute hepatitis case, OR=3.442 (95% CI: 1.638- 7.235). Education is a confounding variable to this relation.