Explorative study to find out the susceptibility pattern of Mycobacterium tuberculosis and the effectiveness of fixed pack of tuberculosis drugs for resistant TB patients, had been conducted at 10 Health Centers in Jakarta. The study was conducted prospectively and the cohort of TB cases were found out by passive case finding method during March-December 1997. Case management carried out complying the TB treatment guidelines at HCs. The HCs were selectedpurposively based on the number of TB patients per month during 1996. The cases being studied consist of cases with no prior treatment and cases with history of one month treatment or more. Sputum AFB confirmation and susceptibility testing had done at Persahabatan Hospital and 10% cross check at Laboratory of Microbiology University of Indonesia. A total of 226 cases out of 330 cases from 10 HCs, met the requirement of the inclusion criteria. More than 50% of the cases were people of productive age. Among the study cases with no prior treatment 15.2% were resistant to at least 1 drug. Among the cases with history of one month treatment or morefefhe resistance prevalence to at least one drug was 4.7%. The total resistance prevalence at 10 HCs was 19.9% (38 cases). Total resistance to isoniazide (INH) was 15.2% and the multi drug resistance (MDR) was 4.7%. The conversion rate of all study cases was 59.3%, 70.8% completed the full course of anti tuberculosis drugs and 20.8% drop out. Among the resistant cases (38 cases), the conversion rate was 47.4% and 63.2% completed the full course. Using Chi square test there was no significant difference statisticaly on conversion rate among the groups of the whole cases, cases with no prior treatment, cases with history of one month treatment or more and the resistant cases. Despite the need for further clinical significance confirmation, the information of non statistical significant difference among the conversion rates of all groups, offered healing expectation for the TB resistant cases if the more strict conditions of case holding management are applied.