In the frame of screening of the medicinal plants efficacy, 19 plants have been tested to see their influence to the normal body temperature of mice. Among the 19 plants there are some medicinal plants which are used as antipyretic by the Indonesian people. Those are Ageratum conyzoides L, Brasica rugosa Prain, Euphatorium triplinerve Vahl, Messua ferrea L and Oroxylum indicum Vent. The administration is intra-peritoneally. Some extract at test dose (1/3 - 1/2) LD 50 decrease the normal body temperature more than 2°C. Most of them happened to be known as antipyretic in traditional medicines.