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      LAPORAN PENDAHULUAN MENGENAI PENDARAHAN PERIRENAL DAN METROPATI PADA GERBIL (MERIONES UNGUICULATUS) DISEBABKAN MIKOTOKSIN PENICILIUM VIRIDICATUM

      Date
      2012
      Author
      Budiarso, Iwan T.; Puslit Kanker dan Pengembangan Radiologi, Badan Litbangkes, Departemen Kesehatan
      Tjokrosapoetro, Roedyanto; Bagian Patologi Anatomik, Fakultas Kedokteran, Universitas Indonesia
      Hassan, Irma; Bagian Patologi Anatomik, Fakultas Kedokteran, Universitas Indonesia
      Sukardi, Frans; Bagian Patologi Anatomik, Fakultas Kedokteran, Universitas Indonesia
      Tedjasukmana, Tjandra; Bagian Patologi Anatomik, Fakultas Kedokteran, Universitas Indonesia
      Tuite, John F.; Department of Botany and Plant Pathology, Perdue University, Lafoyette, Indian - USA
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      Abstract
      Twenty four female gerbils were alloted into 4 groups and each group consisted of 6 animals. Group A was fed with standard diet used as control. Groups B, C and D were fed with diets respectively containing 2,5 %, 5 % and 10 % concentrations of dried ground cultures of Penicillium viridicatum. Three gerbils from each group were killed at the end of 5 and 12 week feeding period respectively. No clinical sign was observed in test groups, other than decrease of body weight. Gross lesions were observed in animals which were killed.at the end of 12 week feeding period. Lesions included hydropic degeneration, hemorrhages, and necrosis of perirenal fatty tissue. The renal parenchyma showed the feature of toxicosis. Microscopic lesions of degeneration, hemorrhages, necrosis and inflammatory cells infiltration of perirenal tissue. The kidney showed focal dilatation and collapse of tubulus.
      URI
      http://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/567
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      • (eJournal 1) Buletin Penelitian Kesehatan [935]

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      Copyright © Badan Litbangkes - Kementerian Kesehatan RI
      Jl. Percetakan Negara no.29, Jakarta Pusat 10560, Indonesia
      All rights reserved. 2019
      Contact Us | Send Feedback