20 YEARS OF PROGRESS IN DENGUE HEMORRHAGIC FEVER AND OTHER ARBOVIRAL DISEASES RESEARCH
Soedarmo, Sumarmo Poorwo; National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia
Gubler, Duane J.; Division of Vector-borne Infectious Diseases, CDC, Fort Collins, Colorado, USA
W., Suharyono; National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia
Suroso, Thomas T.; Directorate General of Communicable Disease Center, and Environmental Health, Ministry of Health, Republic of Indonesia
Samsi, Tatang K.; Sumber Waras Hospital, Jakarta
Masyhur, M.; Regional Health Office, Special Province of Jakarta
Haksohusodo, Suwardji; Faculty of Medicine, Gadjah Mada University, Yogyakarta
Wulur, Hansa; Sumber Waras Hospital, Jakarta
Jennings, Gerald B.; U.S. Naval Medical Research Unit No. 2, Jakarta
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AbstractThroughout the 20 year history of U.S. Naval Medical Research Unit No. 2 Detachment (NAMRU), many viruses and viral diseases have been studied. The greatest emphasis has been in the field of arboviruses, specifically dengue virus, chikungunya virus, and Japanese B encephalitis virus. The initial focus of the work was to define the extent of the threat posed by these viruses. Studies were conducted to determine antibody prevalence, and to determine the etiologies of infectious febrile disease in hospitalized patients. Later the work advanced into more specific areas, especially the entomologic and clinical components of these viruses. Little was known of the incidence or kind of arbovirus infections in Indonesia when NAMRU was established. Previous serological studies had used the cross reactive haemagglutination assay. Green et al. in 1973 provided convincing serological evidence of infections with chikungunya virus and group B arboviruses by using the specific virus neutralization assay. These results demonstrated the need for further studies to isolate the causative agent, to describe the epidemiology, and to investigate the clinical features of the associated disease.
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