Advances in biology sciences over the past decade have provided additional technology for dealing with trematode parasitoses. Although trematode diseases of man and animals in Indonesia are essentially the same as they were ten years ago, scientific methods available to deal with them have improved significantly. One can now exploit the innate ability of cells to replicate and produce biological products upon demand, manipulate the genetic make up of an organism, biologically or synthetically manufacture peptides and rationally develop drugs that target idiosyncrasies of parasites at the cellular and molecular levels. Further, one can now manage and analyze massive amounts of biological data using desk top computers. These new biological techniques and the computing ability to interpret the data generated provide parasitologists in Indonesia and elsewhere with the ability to document the economic and public health impact of trematode parasitoses and to develop new strategies and reagents for diagnosing, treating, preventing and controlling the diseases they cause. In addition, biotechnology offers university scientists and their students with additional opportunities to investigate basic and esoteric aspects of host-parasite interrelationship that are such an intriguing aspect of biology.