View Item 
      •   R2KN Home
      • Kementerian Kesehatan
      • Badan Penelitian dan Pengembangan Kesehatan
      • Jurnal Balitbangkes
      • Buletin Penelitian Kesehatan
      • (eJournal 1) Buletin Penelitian Kesehatan
      • View Item
      •   R2KN Home
      • Kementerian Kesehatan
      • Badan Penelitian dan Pengembangan Kesehatan
      • Jurnal Balitbangkes
      • Buletin Penelitian Kesehatan
      • (eJournal 1) Buletin Penelitian Kesehatan
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      ANTI-NP IMMUNOGLOBULIN GENE : SOMATIC HYPERMUTATION DOES NOT DIRECTLY INFLUENCE ITS SPECIFICITY CHANGE FROM HETEROCLITIC TO HOMOCLITIC

      Date
      2012
      Author
      W.K., Amin Soebandrio; Division of Immunology, Department of Microbiology, Medical Faculty, University of Indonesia
      Metadata
      Show full item record
      Abstract
      It is generally accepted mat in the maturation of an immune response, the quality of the antibody, as well as the quantity, will improve with time after immunization. In the mouse system, immunoglobulin obtained in the first days after immunization with NP-CGG showed greater specificity to NTP-CGG (heteroclitic specificity). While the specificity to the immunizing antigen (homoclitic specificity) was recovered few weeks later. Intensive study on its immunoglobulin structure and the sequences of its mRNA revealed that this change of specificity was due to the switch from kappa to lambda light chain rather than to the occurence of somatic hypermutation in the immunoglobulin gene. In this paper, we describe the contribution of either somatic hypermutation or immunoglobulin light chain class switch to the change of specificity from heteroclitic to homoclitic.
      URI
      http://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/664
      Collections
      • (eJournal 1) Buletin Penelitian Kesehatan [935]

      Copyright © Badan Litbangkes - Kementerian Kesehatan RI
      Jl. Percetakan Negara no.29, Jakarta Pusat 10560, Indonesia
      All rights reserved. 2019
      Contact Us | Send Feedback
        

       

      Browse

      All of R2KNCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

      My Account

      LoginRegister

      Copyright © Badan Litbangkes - Kementerian Kesehatan RI
      Jl. Percetakan Negara no.29, Jakarta Pusat 10560, Indonesia
      All rights reserved. 2019
      Contact Us | Send Feedback