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dc.contributorBADAN LITBANGKES KEMENKESid-ID
dc.creatorW.K., Amin Soebandrio; Division of Immunology, Department of Microbiology, Medical Faculty, University of Indonesia
dc.date2012-09-20
dc.date.accessioned2019-12-16T09:31:12Z
dc.date.available2019-12-16T09:31:12Z
dc.identifierhttp://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/664
dc.identifier10.22435/bpk.v17i2 Jun.664.
dc.identifier.urihttp://r2kn.litbang.kemkes.go.id:8080/handle/123456789/80562
dc.descriptionIt is generally accepted mat in the maturation of an immune response, the quality of the antibody, as well as the quantity, will improve with time after immunization. In the mouse system, immunoglobulin obtained in the first days after immunization with NP-CGG showed greater specificity to NTP-CGG (heteroclitic specificity). While the specificity to the immunizing antigen (homoclitic specificity) was recovered few weeks later. Intensive study on its immunoglobulin structure and the sequences of its mRNA revealed that this change of specificity was due to the switch from kappa to lambda light chain rather than to the occurence of somatic hypermutation in the immunoglobulin gene. In this paper, we describe the contribution of either somatic hypermutation or immunoglobulin light chain class switch to the change of specificity from heteroclitic to homoclitic.id-ID
dc.formatapplication/pdf
dc.languageid
dc.publisherBadan Penelitian dan Pengembangan Kesehatanen-US
dc.rightsThe Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development) as publisher of the journal.Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc. , will be allowed only with a written permission from Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development).Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development), the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal.
dc.sourceBuletin Penelitian Kesehatan; Vol 17, No 2 Jun (1989)en-US
dc.subjectHealth; Kesehatanid-ID
dc.subjectSomatic Hypermutation; Heteroclitic; Homocliticid-ID
dc.subjectid-ID
dc.titleANTI-NP IMMUNOGLOBULIN GENE : SOMATIC HYPERMUTATION DOES NOT DIRECTLY INFLUENCE ITS SPECIFICITY CHANGE FROM HETEROCLITIC TO HOMOCLITICid-ID
dc.typeid-ID
dc.typeen-US


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