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dc.contributoren-US
dc.creatorWahyuningrum, Sri Nuryani; Balai Litbang GAKI (Gangguan Akibat Kekurangan Iodium) Kapling Jayan, Borobudur, Magelang 56553 Indonesia
dc.creatorWibowo, R. Agus; Balai Litbang GAKI (Gangguan Akibat Kekurangan Iodium) Kapling Jayan, Borobudur, Magelang 56553 Indonesia
dc.creatorHidayat, Taufiq; Balai Litbang GAKI (Gangguan Akibat Kekurangan Iodium) Kapling Jayan, Borobudur, Magelang 56553 Indonesia
dc.date2015-04-20
dc.date.accessioned2019-12-16T09:33:31Z
dc.date.available2019-12-16T09:33:31Z
dc.identifierhttp://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/3962
dc.identifier10.22435/bpk.v43i1.3962.1-10
dc.identifier.urihttp://r2kn.litbang.kemkes.go.id:8080/handle/123456789/80815
dc.descriptionAbstractSpirulina is seawater microalgae that have potential as natural source of iodine and contain of 94.5 ppm iodine. The purpose of this study was to determine the effect of spirulina consumption on TSH and fT4 level at women of childbearing age in IDD (Iodine Deficiency Disorder) endemicarea, who at risk of hypothyroidism. This is a Randomized Control Trial (RCT), double-blind research. Subjects were women of childbearing age (18-40 years), with TSH levels 3 to 6.2 μIU /L, divided into 2 groups. The control group was given placebo and the treatment group were given spirulina, 1 g/day, for 3 months. Spirulina and placebo were capsulated in similar capsul. TSH and FT4 levels were analyzed by ELISA method from blood serum samples. Two cc of blood were taken from subject’s arm vein. The results showed that spirulina supplementation did not affect TSH levels (P > 0.05), but increasing thyroid hormone levels (fT4) higher than the control group (P < 0.05). Spirulina can be used as alternative source of iodine beside salt fortification to improve thyroid function.Keywords : iodine, fT4, spirulina, TSHAbstrakSpirulina merupakan mikroalga berasal dari laut yang berpotensi menjadi sumber iodium alami dengan kandungan iodium sebesar 94,5 ppm. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh konsumsi spirulina terhadap kadar TSH dan fT4 pada wanita usia subur yang beresiko hipotiroid. Jenis penelitian adalah Randomized Control Trial (RCT) double blind. Subyek penelitian adalah Wanita Usia Subur (WUS) usia 18 - 40 tahun, mempunyai kadar TSH 3-6,2 μIU/L, dibagi menjadi 2 kelompok. Kelompok kontrol diberi plasebo dan kelompok perlakuandiberi spirulina, sebanyak 1 gr/hr, selama 3 bulan. Spirulina dan plasebo dikemas dalam bentuk kapsul yang serupa. Kadar TSH dan fT4 dianalisis dengan metode ELISA dari sampel serum darah subyek. Darah subyek diambil dari pembuluh vena lengan sebanyak 2 cc. Hasil penelitianmenunjukkan bahwa pemberian spirulina tidak mempengaruhi kadar TSH (P > 0,05), namun dapat meningkatkan kadar hormon tiroid fT4 lebih tinggi dibandingkan kelompok kontrol (P < 0,05). Spirulina bisa menjadi alternatif sumber iodium selain garam untuk meningkatkan fungsitiroid.Kata kunci : iodium, fT4, spirulina, TSHen-US
dc.formatapplication/pdf
dc.languageen
dc.publisherBadan Penelitian dan Pengembangan Kesehatanen-US
dc.rightsThe Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development) as publisher of the journal.Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc. , will be allowed only with a written permission from Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development).Buletin Penelitian Kesehatan (Bulletin of Health Research) and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development), the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal.
dc.sourceBuletin Penelitian Kesehatan; Vol 43, No 1 (2015); 1-10en-US
dc.subjecten-US
dc.subjectiodium, fT4, spirulina, TSHen-US
dc.subjecten-US
dc.titleFLUKTUASI KADAR TSH DAN FREE T4 SELAMA SUPLEMENTASI SPIRULINA SEBAGAI SUMBER IODIUM ALAMI PADA WANITA USIA SUBUR DI DAERAH ENDEMIK GAKIen-US
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dc.typeen-US


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