Abstract

Abstract The soursop leaves (Annona muricata L.) are part of soursop plants that have a potential to be developed as anticancer as it contains annonacin. Annonacin is one of the acetogenins compounds group that are cytotoxic and mostly can be found in soursop plants. In the development of pharmaceutical preparation, apart from their safety and efficacy, quality of medicinal raw materials has been one of the important factors. Soursop leaf extract quality can be affected by their types of growing places. Therefore, the research of the quality characterization of soursop leaf extracts from three different growing places needs to be done in order to identify the quality of the extract used as herbal medicines. Quality inspection of soursop leaf extracts was including non-specific and specific parameters. Soursop leaf samples were obtained from three growing places with different altitude, which were from Tawangmangu, Central Java,; Pasuruan, East Java; and Bogor, West Java.The results showed that the best leaf extracts of soursop was from Pasuruan with non-specific parameters: (water content of 7,15% , ash content of 3,59% and 0,44 ppb levels of aflatoxin G2, and specific parameters: (the concentration of annonacin is 12,80%). Keywords: soursop leaf, annonacin, characterization, quality extractsAbstrakDaun sirsak (Annona muricata L.) merupakan bagian dari tanaman sirsak yang berpotensi untuk dikembangkan sebagai antikanker karena mengandung annonacin. Annonacin adalah salah satu senyawa golongan acetogenins yang bersifat sitotoksik dan paling banyak terkandung dalam tanaman sirsak. Dalam pengembangan sediaan obat, mutu bahan baku obat merupakan salah satu faktor penting, selain keamanan dan efektifitas. Mutu ekstrak daun sirsak dapat dipengaruhi oleh perbedaan tempat tumbuh. Oleh karena itu, penelitian karakterisasi terhadap mutu ekstrak daun sirsak pada tiga tempat tumbuh perlu dilakukan untuk mengidentifikasi mutu ekstrak yang digunakan sebagai obat herbal. Pemeriksaan mutu ekstrak daun sirsak mencakup parameter non spesifik dan spesifik. Sampel daun sirsak diperoleh dari tiga tempat tumbuh dengan ketinggian yang berbeda, yaitu daerah Tawangmangu, Jawa Tengah; Pasuruan, Jawa Timur; dan Bogor, Jawa Barat. Hasil penelitian menunjukkan bahwa ekstrak daun sirsak yang paling baik adalah ekstrak dari daerah Pasuruan dengan parameter non spesifik: (kadar air 7,15%, kadar abu 3,59%, kadar aflatoksin G2 0,44 ppb), dan parameter spesifik: (kadar annonacin sebesar 12,80%).Kata kunci: daun sirsak , annonacin, karakterisasi, mutu ekstrak