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dc.creatorSantoso, Santoso; Vector Borne Disease Control Research and Development Council, Baturaja, South Sumatra
dc.identifier10.22435/hsji.v1i1 Des.31.26-32
dc.descriptionAbstrak Latar belakang: Pengobatan malaria di Kabupaten OKU sejak tahun 2009 telah menggunakan artesdiakuin untuk malaria vivak dan malaria falsiparum. Penelitian bertujuan untuk mengetahui perbedaan gejala klinis awal penderita malaria vivak dan malaria falsiparum, efektivitas dan efek samping pemberian artesdiakuin. Metode: Penelitian merupakan kuasi eksperimen menggunakan metode pre-post test. Sampling dilakukan secara consecutive terhadap pasien Puskesmas Pengaringan, OKU selama bulan Februari sampai Juni 2010. Diagnosis malaria didasarkan adanya plasmodium pada darah pasien secara mikroskopis. Seluruh pasien yang didiagnosis malaria diterapi artesdiakuin pada H0 sampai H2 sedangkan pemberian primakuin hanya dilakukan pada H0. Pengamatan dilakukan i selama 28 hari yaitu pada H0 sampai H3, H7, H14, H21 dan H28. Pengamatan efek samping dilakukan pada H0 sampai H3 sedangkan penilaian efikasi obat dilakukan setelah H28. Hasil: Diperoleh jumlah penderita malaria falsiparum sebanyak 23 orang dan malaria vivak sebanyak 12 orang. Gejala klinis awal sebelum terapi ditemukan pada 91,3%  pada subjek dengan malaria falciparum berupa menggigil, anoreksia, sakit kepala, pusing dan nyeri otot. Gejala tersebut terjadi pada 50% subjek dengan malari vivak. Obat anti-malaria artesdiakuin memiliki efikasi yang baik (100%) terhadap penderita malaria vivax namun pada penderita malaria falsiparum hanya diperoleh 87%. Efek samping artesdiakuin ditemukan berupa gatal, pusing, mual, muntah dan nyeri lambung. Efek samping obat lebih berat pada penderita malaria falsiparum dibandingkan malaria vivak. Kesimpulan: Penderita malaria vivax lebih banyak yang tidak mengalami gejala klinis awal. Artesdiakuin lebih efektif pada penderita malaria vivak dibandingkan penderita malaria falsiparum. Efek samping yang ditemukan berupa menggigil, anoreksia, sakit kepala, pusing dan nyeri otot. (Health Science Indones 2010; 1: 26 -32) Kata kunci: malaria, artesdiakuin, efektivitas, efek samping   Abstract Background: Malaria treatment in Souh Sumatra has been using artesdiaquine since 2009 for falciparum and vivax malaria. This study is aimed to examine the comparison of the effectiveness of anti-malaria drugs artesdiaquine and its side effects between falciparum malaria and vivax malaria treatment. Methods: This consecutive sampling quasi experimental research was conducted during February to June 2010 in a district of South Sumatra (Indonesia). Diagnosis based on peripheral blood smear plasmodium finding. All patients positive for Plasmodium were observed for 28 days: 0-3 (D0) to 3th (D3), 7th (D7), 14th (D14), 21th (D21) and 28th day (D28). Therapy of artesdiaquine on D0 to D2, while primaquine was only gives on D0. The observations of side effects were done on D0 to D3. The assessments of drug efficacy were immediately after D28. Results: Twenty three falciparum malaria patients and and twelve  vivax malaria patients were included as study subjects Initial clinical symptoms of chills, headache, dizziness, anorexia, and muscle aches were found in falciparum malaria subjects and vivax malaria subjects were 91.3% and 50% respectively. The results showed anti-malaria drugs artesdiaquine had 100% efficacy of vivax malaria patients however for falciparum malaria acquired was only 87%. Artesdiaquine side effects consisted of itching, dizziness, nausea, vomiting, and stomach pain, were more prevalent in patients with falciparum malaria than vivax malaria. Conclusion: The number of malaria vivax patients less clinical symptoms occurred than falciparum malaria. The effectiveness of artesdiaquine anti malaria drugs combination for vivax malaria was better than falciparum malaria. (Health Science Indones 2010; 1: 26 - 32)id-ID
dc.publisherBadan Penelitian dan Pengembangan Kesehatanen-US
dc.rightsThe Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Health Science Journal of Indonesia and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development) as publisher of the journal.Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc. , will be allowed only with a written permission from Health Science Journal of Indonesia and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development).Health Science Journal of Indonesia and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development), the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal.
dc.rightsUnder the terms of Indonesian Goverment Copyright Law, Health Science Journal of Indonesia must formally obtain transfer of copyright before an article can be published. Health Science Journal of Indonesia grants to the author (and to all coauthors) the right to present orally in any forum all or part of the work. It is also stipulated that all graphics including figures, tables and charts may be republished with permission from Health Science Journal of Indonesia. In consideration of the fact that Health Science Journal of Indonesia undertakes to publish my article: I affirm that the material has not been previously published and that I (and my coauthors) own and have not transferred elsewhere any rights to the article.I affirm that I (and my coauthors) have obtained written permission to use any previously copyrighted material included in the article and that such documentation will be forwarded to Health Science Journal of Indonesia simultaneously with the article. I further affirm that I (and my coauthors) have stated any possible conflicts of interest within the article.I (and my coauthors) hereby assign and transfer to Health Science Journal of Indonesia all rights of copyright ownership and permission to the article, including without limitation or restriction, all rights of reproduction, derivation, distribution, sale, reuse, and display of the of the work, in whole or in part, including recompilation and stand-alone publication, in any and all forms of media now or hereafter known, including all electronic and digital media, as protected by the laws of the Republic of Indonesia and foreign countries and to authorize others to make such uses of the work. These rights will become the property of Health Science Journal of Indonesia from the date of acceptance of the article for publication and extend for the life of the copyright. I understand that Health Science Journal of Indonesia, as copyright owner, has authority to grant permission to reproduce the article.
dc.sourceHealth Science Journal of Indonesia; Vol 1, No 1 Des (2010); 26-32en-US
dc.sourceHealth Science Journal of Indonesia; Vol 1, No 1 Des (2010); 26-32id-ID
dc.subjectHealth; kesehatanid-ID
dc.subjectmalaria, artesdiaquine, effectiveness, side effectsid-ID
dc.titleArtesdiaquine and Primaquine combined treatment is more effective for Malaria vivaxid-ID
dc.typePeer-reviewed Articleen-US

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