Abstract. Malaria is an infectious disease caused by Plasmodium spp, are naturally transmitted by the mosquito Anopheles spp. Malaria transmission occurs because of interaction between the agent, the definitive host and intermediate hosts (humans). Therefore, the transmission of malaria is injluenced by the presence and fluctuations in vector populations (i.e transmitting mosquito Anopheles spp).Malaria diagnosis consists of clinical diagnosis and diagnosis based on laboratory examination. Clinical diagnosis or clinical malaria diagnosis was presumptive diagnosis of malaria based on clinical examination of patients with symptoms include fever (periodical), heat, level of consciousness, dizziness, etc. as well as specific local typical symptoms. Experiences of medical personnel who perform precise diagnosis will determine whether or not the diagnosis, so that clinical diagnosis cannot be the main reference in the treatment of malaria because of high error rates.