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dc.contributorBADAN LITBANGKES KEMENKESid-ID
dc.creatorSetyawan, Dwi; Departemen Farmasetika Fakultas Farmasi Universitas Airlangga
dc.creatorIsadiartuti, Dewi; Departemen Farmasetika Fakultas Farmasi Universitas Airlangga
dc.date2012-10-31
dc.date.accessioned2019-12-17T10:27:30Z
dc.date.available2019-12-17T10:27:30Z
dc.identifierhttp://ejournal.litbang.depkes.go.id/index.php/jki/article/view/1290
dc.identifier10.22435/jki.v1i1.1290.
dc.identifier.urihttp://r2kn.litbang.kemkes.go.id:8080/handle/123456789/83127
dc.descriptionCharacterization of mefenamic acid-β-cyclodextrin inclusion complexes by freeze drying method had been studied. Solid state mefenamic acid- β-cyclodextrin inclusion complex prepared by freeze drying method in 1:1 molar ratio. Mefenamic acid, β-cyclodextrin, mefenamic acid-β-cyclodextrin physical mixture and inclusion complexes were charac­terized by Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy (FTIR) , Differential Thermal Analyzer (DTA) and dissolution studies. The results showed the formation of inclusion complex between mefenamic acid and β-cyclodextrin. In vitro dis­solution rate studies of mefenamic acid, mefenamic acid-β-cyclodextrin physical mixture and inclusion complex were conducted using basket method and water as dissolution medium. Mefenamic acid-β-cyclodextrin inclusion complex showed increasing dissolution rate compared to mefenamic acid-β-cyclodextrin physical mixture and mefenamic acid.   Key words: mefenamic acid, β-cyclodextrin, freeze drying, inclusion complex, dissolution rateid-ID
dc.formatapplication/pdf
dc.languageid
dc.publisherCenter for Biomedical and Basic Technology of Health,National Institute of Health Researchen-US
dc.sourceJurnal Kefarmasian Indonesia; Vol 1, No 1 (2009)id-ID
dc.sourceJurnal Kefarmasian Indonesia; Vol 1, No 1 (2009)en-US
dc.titleKarakterisasi Kompleks Inklusi Asam Mefenamat - β -Siklodekstrin yang Dibuat dengan Metode Freeze Dryingid-ID
dc.typePeer-reviewed Articleen-US


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