AKTIVITAS KONTRAKTILITAS AORTA PADA EKSTRAK DAUN Androgrophis paniculata

Date
2008
Author
Kosala, Khemasili; Dosen Farmakologi Program Studi Kedok­teran Umum Universitas Mulawarman, Samarinda
Ismail, Sjarif; Dosen Farmakologi Program Studi Kedok­teran Umum Universitas Mulawarman, Samarinda
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Abstract
Andrographis paniculata leaves are often used as an anti-hypertension medicine. However, its effects in the blood vessels are not clearly known. This research was aimed to measure the activities of Andrographis paniculata leaves extract on blood vessels contractility. Andrographis paniculata leaves were macerated with CHCl3:  Me-OH (1:1), and tested for ther effects on the contractility of the isolated organ of rabbit's aortic ring with endothelium. The result showed that Andrographis paniculata leaves extract didn't cause tone change and increase dilatation response on the isolated organ of rabbit's aortic ring with endothelium. Andrographis paniculata didn't have direct vasodilatation on blood vessels in vitro.   Keywords: Andrographis paniculata, contractility, aortic ring
URI
http://ejournal.litbang.depkes.go.id/index.php/toi/article/view/1267
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