Lansium domesticum cortex was empirically used by people on the Pakuli region of Palu to reduced pain on malaria treatment. The analysis of chemicals and physical properties Lansium domesticum cortex has been conducted. The aim of this research was to analyze chemicals and physical properties of Lansium domesticum cortex. The physical properties were rendement, water soluble compound content, water in-soluble compound content, total ash content, acid in-soluble ash content. The chemicals properties comprised chemical analysis of the constituent of Lansium domesticum cortex. Based on this study, we found that Lansium domesticum cortex contains saponin, flavonoide, tannin and antraquinone. The extract rendement by 70% alcohol was 17,33 + 0,63%, water soluble compound content was 20,42 + 0,08%, water in-soluble compound content was 13,16 + 0,09%, total ash content was 1,85+ 0,20% and acid in-soluble ash content was 0,76 + 0,23% respectively.