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      Hypoglycaemic activity of aqueous extract of leafs of Strobilanthes crispa L. in male Wistar rats using glucose tolerance test method

      Date
      2011
      Author
      Sutjiatmo, Afifah B; Department of Pharmacy, Universitas Jenderal Ahmad Yani, Cimahi, Indonesia
      Wahyuningsih, Sri; Department of Pharmacy, Universitas Jenderal Ahmad Yani, Cimahi, Indonesia
      Vikasari, Suci Nar; Life Science Center, Institut Teknologi Bandung, Indonesia
      Wijayanti, Sri; Department of Pharmacy, Universitas Jenderal Ahmad Yani, Cimahi, Indonesia
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      Abstract
      ABSTRACTExtract of has been used traditionally to treat diabetes mellitus and gallstones. The objective of this study is to test hypoglycemic effect of aqueous extract of leafs of S. crispa in rats using glucose tolerance test method. Aqueous extract of leafs of S. crispa L. at doses 150 mg/kg bw and 300 mg/kg bw were orally administered in male Wistar rat. Blood glucose rate was analysed every 60 minutes over 3 hours. As conclusion, aqueous extract of leafs of S. crispa at dose 150 mg/kg bw gave similar effect with chlorpropamid at dose 9 mg/kg bw.ABSTRAKDaun Strobilanthes crispa L. digunakan dalam pengobatan tradisional untuk mengatasi diabetes dan batu ginjal. Penelitian ini bertujuan untuk mengetahui efek hipoglikemik ekstrak air daun Strobilanthes crispa L. pada tikus betina galur Wistar dengan metode toleransi glukosa. Ekstrak dosis 150 dan 300 mg/kg bb masing-masing diberikan p.o pada tikus betina. Analisa peningkatan glukosa darah dilakukan setiap 60 menit selama 3 jam. Kesimpulan penelitian ini, ekstrak air daun Strobilanthes crispa L. dosis 150 mg/kg bb memiliki efek yang setara dengan klorpropamid dosis 9 mg/kg bb.
      URI
      http://ejournal.litbang.depkes.go.id/index.php/toi/article/view/8802
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      • (eJournal 1) Jurnal Tumbuhan Obat Indonesia [163]

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      Copyright © Badan Litbangkes - Kementerian Kesehatan RI
      Jl. Percetakan Negara no.29, Jakarta Pusat 10560, Indonesia
      All rights reserved. 2019
      Contact Us | Send Feedback