Abstract

AbstrakTelah dilakukan penelitian tentang struktur histologi hepar (hati) tikus rumah (Rattus tanezumi) infektif Leptospira spp.  Tujuan  penelitian  untuk  mengetahui  perubahan  struktur  jaringan  hepar  R.  tanezumi  akibat  patogenitas bakteri Leptospira spp. Penangkapan tikus dilakukan di Kelurahan Miroto, Kecamatan Semarang Tengah, Kota Semarang. R. tanezumi diambil heparnya dan selanjutnya dibuat sediaan histologis dengan metode parafin dan pewarnaan HE (Hematoxylin Eosin). Data dianalisis secara deskriptif yaitu mencandra gambaran histologis hepar  R  tanezumi  infektif  Leptospira  patogenik.  Hasil  penangkapan menunjukkan  bahwa  R.  tanezumi  yang tertangkap sebanyak 8 ekor, dan 2 ekor infektif Leptospira patogenik. Hasil pemeriksaan histologis menunjukkan bahwa sebagian sel hepar R. tanezumi infektif Leptospira patogenik terjadi degenerasi melemak.Kata kunci: Hepar, Leptospira, Rattus tanezumiAbstractThe study on the histological structure of Rattus tanezumi liver infected by Leptospira spp was conducted. The purpose of this study was to determine the change of hepar tissue structure of R. tanezumi due to the patogenikity of Leptospira spp bacteria. The rats were collected from Miroto region, Central Semarang District, Semarang Municipality. R. tanezumi were caught and their hepar were taken, then histological preparat were made using paraffin and HE staining method. The data were collected qualitatively and then analyzed descriptively by describing histological hepar appearance of R. tanezumi which were infected by Leptospira spp. The results of this research show that 8 individuals of R. tanezumi caught and 2 induvidual infected by Leptospira spp. The results of R. tanezumi histological hepar examination which were infected by Leptospira spp. show fat degeneration in part of hepar cell.Key words: Hepar, Leptospira, Rattus tanezumi