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dc.contributoren-US
dc.creatorMulyono, Arief; Balai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit Salatiga
dc.date2015-03-18
dc.date.accessioned2019-12-17T10:45:03Z
dc.date.available2019-12-17T10:45:03Z
dc.identifierhttp://ejournal.litbang.depkes.go.id/index.php/vk/article/view/3788
dc.identifier10.22435/vektora.v6i1 Jun.3788.19-26
dc.identifier.urihttp://r2kn.litbang.kemkes.go.id:8080/handle/123456789/83635
dc.descriptionENGLISHAbstractNS1 protein is a multifunction protein that plays key role of pathogenesis and virulence of avians influenza virus H5N1. The amino acid substitution at the position P42S, D92E, F103I, M106I and 5 amino acid deletion at the position 80 to 84 in NS1 protein reported increasing virulence of avians influenza virus H5N1. Several studies showed avians influenza virus H5N1 in Indonesia has dynamic changed. This study aimed to analyze the markers of virulence of NS1 protein sequences of all H5N1 virus isolates from Indonesia. The source of NS1 protein sequence data gene obtained from GeneBank and Gisaid. Data were analyzed using Bioedit software. The Results showed the isolates from Indonesia had substitutions P42S and 5 amino acids deletions at positions 80-84 resulting in the potential for increased virulence of the virus. However, amino acid substitution at the position D92E, F103L and M106I substitution were not found.INDONESIANAbstrakProtein NS1 adalah protein multifungsi yang memainkan peran kunci dalam patogenesis dan virulensi virus avian influenza H5N1. Substitusi asam amino P42S, D92E, F103I, M106I, dan delesi 5 asam amino di posisi 80 - 84 dilaporkan meningkatkan virulensi virus avian influenza H5N1. Beberapa penelitian menunjukkan bahwa virus avian influenza di Indonesia mengalami perubahan dinamis. Studi ini akan menganalisis motif asam amino yang menjadi penanda peningkatan virulensi pada sekuen protein NS1 virus avian influenza H5N1 asal Indonesia. Data sekuen asam amino protein NS1 diperoleh dari database GeneBank dan Gisaid. Analisis data menggunakan Bioedit software. Hasil analisis menunjukkan subtitusi asam amino dari prolin ke serin di posisi 42 (P42S) dan delesi 5 asam amino di posisi 80 – 84 telah ditemukan pada virus avian influenza asal Indonesia, akan tetapi tidak ditemukan substitusi asam amino aspartat ke glutamat diposisi no 92 (D92E) dan tidak ada yang mengalami 2 substitusi asam amino sekaligus diposisi 103 dan 106.en-US
dc.formatapplication/pdf
dc.languageen
dc.publisherBalai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit (B2P2VRP) Salatigaen-US
dc.rightsThe Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to VEKTORA and Balai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit (Institute of Vector and Reservoir Control Research and Development) as publisher of the journal. Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc. , will be allowed only with a written permission from VEKTORA (Journal of Vector Borne and Reservoir Diseases) and Balai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit (Institute of Vector and Reservoir Control Research and Development). VEKTORA (Journal of Vector Borne and Reservoir Diseases) and Balai Besar Penelitian dan Pengembangan Vektor dan Reservoir Penyakit (Institute of Vector and Reservoir Control Research and Development), the Editors and the Advisory International Editorial Board make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal.
dc.sourceVektora : Jurnal Vektor dan Reservoir Penyakit; Vol 6, No 1 Jun (2014); 19-26en-US
dc.sourceVektora; Vol 6, No 1 Jun (2014); 19-26id-ID
dc.subjecten-US
dc.subjectH5N1, NS1, Indonesiaen-US
dc.subjecten-US
dc.titleDetection of Markers of Increased Virulence Non Structural protein (NS I) Avian Influenza Virus H5N1 from Indonesia=DETEKSI PENANDA PENINGKATAN VIRULENSI NON STRUKTURAL PROTEIN (NS1) VIRUS AVIAN INFLUENZA H5N1 ASAL INDONESIAen-US
dc.typeen-US


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