Abstract

Schistosomiasis infects 261 million people in 78 countries with 600 million people at risk of infection. Schistosomiasis in Indonesia is due to blood trematode Schistosoma japonicum and Oncomelania hupensis lindoensis snail as intermediate host .Schistosomiasis control is conducted by the management of environment as well as treatment with praziquantel. The long periode and continously drug use may result in drug resistance. Based on these, vaccines against schistosomiasis, as schistosomiasis control strategies in the future, is needed. This review was aimed to describe some of the vaccine candidates against S. japonicum with their level of efficacy, which composed by many schistosomiasis vaccine-related scientific literature. Schistosomiasis vaccine candidate proteins showed varying levels of efficacy and no one has the most potential. Although the development of vaccines against schistosomiasis is quite difficult, the research must still be continued