Transmission of dengue virus is more prevalent in the home, so that the home environmental affects the morbidity of dengue hemorrhagic fever, although still dependent on other factors. This study aims to determine the relationship of the household density, abiotic environment and the presence of larvae of house mosquito Aedes spp against dengue virus infection. The study was conducted in Cirebon regency with cross sectional design. Respondents were asked the wide of house and number of occupants, then calculated the house density. Subsequently measured lighting, temperature and humidity inside the house and observed the presence of water containers are not covered as well as the presence of mosquito larvae of Aedes spp. The number of respondents was 200 persons consisting of 86 men ans 114 women. Known, respondents with not normal nutritional status is 68 respondents (34%) and normal categories was 132 (66%); in age group <5 years in 193 respondents (96,50%) and 161 respondents (80,50%) is negatif. Bivariate analysis showed the nutritional status and age groups are each associated with dengue virus infection status, the most influential is the age group. In addition, it was examined the blood samples using a rapid diagnostic test to find out the status of dengue virus transmission. The resulting data, analysed to determine the relationship between the independent variables with the dependent variable. It was concluded, the density of the household, home lighting, and humidity shown to be associated with dengue virus infection status. Dense homes and homes with optimal light for the development of Aedes spp is a risk factor for the occurrence of dengue virus infection.