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dc.creatorWibowo, R. Agus; Balai Litbang GAKI Magelang
dc.creatorWahyuningrum, Sri Nuryani; Balai Litbang GAKI Magelang
dc.descriptionABSRACT Iodine Deficiency Disorder (IDD) is still a public health problem in Indonesia. Salt iodization was one of IDD prevention programme to prevent IDD, however the national coverage for iodized salt is still less than 90%. Alternative solution to solve IDD elimination is needed to find a better iodine sources. One of nutrient rich source from the sea that was developed to improve the nutritional status is Spirulina sp. Spirulina has high bioavailability due to the simple structure of the cell wall, so that the nutrients contained iodine will be more easily absorbed by the body. The aim of this research was to describe the effect of Spirulina sp to free T4 and thyroglobulin level in women of child bearing age in Kalibawang Kulon Progo regency. This is an experimental study using double blind randomized control trial (RCT). Subjects are euthyroid child bearing woman (18-40 years old), with TSH levels of 3 to 6.2 μIU/L. They were divided into 2 groups with subjects in control group were given placebo while the treatment group were given Spirulina sp (1 gr/day) for 3 months. Serum for free T4 and thyroglobulin was analysed using ELISA. The results showed that there were significant changes in free T4 level in both groups after intervention (P <0.05), but there were no significant differences between the two groups at the beginning and end of treatment (P> 0.05) in thyroglobulin. The intervention using Spirulina sp has potential effect to increase free T4 level, however it did not effect thyroglobulin level. Keywords: FreeT4, RCT, Spirulina sp, Thyroglobulin   ABSTRAK   Masalah kekurangan asupan iodium dan gangguan akibat kekurangan iodium (GAKI) masih menjadi masalah di Indonesia. Program iodisasi garam merupakan salah satu program yang dijalankan oleh pemerintah Indonesia untuk menanggulangi GAKI, namun sampai saat ini cakupan angka nasional untuk garam beriodium belum mencapai 90%. Dibutuhkan metode baru yang efektif dalam membantu program penanggulangan GAKI dengan menemukan alternatif sumber iodium baru. Salah satu sumber Iodium banyak terdapat pada produk sumber daya laut, antara lain adalah Spirulina. Spirulina mempunyai bioavailabilitas yang tinggi karena struktur sel yang sederhana memudahkan nutrient berisi iodine diabsorbsi oleh tubuh. Tujuan dari penelitian adalah mengetahui dampak intervensi Spirulina sp terhadap tiroglobulin dan T4 bebas. Penelitian ini adalah penelitian eksperimen dengan metode double blind randomized control trial (RCT). Subyek adalah wanita usia subur (WUS) usia 18-40 tahun di Kabupaten Kulon Progo, Propinsi Daerah Istimewa Yogyakarta (DIY) yang beresiko hipotiroid. Kelompok dibagi menjadi dua yaitu kelompok intervensi   dan kontrol. Kelompok kontrol diberi plasebo dan kelompok perlakuan diberi spirulina, masing-masing 1 gr/hr selama 3 bulan. T4 bebas dan tiroglobulin dianalisa dengan metode ELISA. Hasil penelitian menunjukkan perbedaan bermakna antara kelompok kontrol dan kelompok intervensi terhadap perubahan kadar T4 bebas (P<0.05), namun tidak bermakna pada kadar tiroglobulin (P>0.05). Spirulina berpotensi meningkatkan kadar T4 bebas, namun tidak berpengaruh terhadap kadar tiroglobulin. Kata Kunci: Spirulina sp, tiroglobulin, T4 bebas, RCTen-US
dc.publisherBalai Penelitian dan Pengembangan Gangguan Akibat Kekurangan Iodiumen-US
dc.rightsMedia Gizi Mikro Indoesia (MGMI) Journal provides immediate open access to its content on the principle that making research freely available to the public supporting a greater global exchange of knowledge.All articles published Open Access will be immediately and permanently free for everyone to read and download.  We are continuously working with our author communities to select the best choice of license options, currently being defined for this journal as follows:• Creative Commons Attribution (CC-BY-SA)The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to MGMI Journal and Badan Penelitian dan Pengembangan Kesehatan (National Institute of Health Research and Development) as publisher of the journal.  
dc.sourceMedia Gizi Mikro Indonesia; Vol 5, No 2 (2014)id-ID
dc.sourceMedia Gizi Mikro Indonesia; Vol 5, No 2 (2014)en-US
dc.titleDampak Intervensi Sumber Iodium Alami Spirulina sp terhadap Kadar T4 Bebas (FT4) dan Tiroglobulin (TG) pada Wanita Usia Subur di Daerah Kalibawang Kulon Progoen-US

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