Clinical management for children with developmental disorder, including laser puncture, medical treatment, nutrition, psychological counseling, or physiotherapy, had been instigate by BP2GAKI. There was no previous research on evaluating the long term outcome of children growth and development who had completed the clinical management in BP2GAKI. Objectives of this study are to investigated the long term effect of therapy administered in BP2GAKI, which were growth, development, hypothyroidism clinical sign, and iodine status. This study was observational with a cross sectional study conducted in BP2GAKI Magelang on 2008. Sample of this study were 44 children based on sample size of Dahlan, patients in BP2GAKI clinique from the year 2002-2005 who completed treatment with ≥40 times therapy and TSH level of ≥5 μIU/mL. Growth status were measured with anthropometrical data of weight and height, developmental data were assessed with Denver 2. Indicators significant of hypothyroid were assessed with clinical score, and iodine status was measured with TSH level. Data was analyzed with chi square test. The result is nutritional status within normal category was increased from 47.73% to 68.18%. Before treatment all children was developmental delayed. Recent data showed that normal motor development was increased significantly to 63.64% (p<0.05 (95% CI: 0.818-7.851). The normal social and language development were increased significantly to 38.64%. Clinical categories with normal score decreased significantly from 45.46% to 40.91% (p<0.05; 95% CI: -0.965-(-0.81). The normal iodine state was 56.82% and children with hypothyroid was decreased significantly from 100% to 43.18% (p<0.05 (95% CI: 0.461-0.748). There was improvement in nutritional status, motor, language, and social development in children long term after treatment in BP2GAKI. Improvement also found in iodine status, but clinical score for hypothyroid was worsen.