To produce a stable high iodized salt, raw materials with minimum 94.5% NaCl content is needed. The substances causing loss of iodine in iodized salt are Ca and Mg. These substances are formed simultaneously with the formation of NaCl crystals in the salt fields due to the salt coprecipitation. UNICEF 2006 stated that approximately 75% of raw material salt used for iodized salt industry in 11 salt-producing regencies in Indonesia has NaCl content less than 94.5% means the ca and mg content are still quite high. Center for industrial Pollution Technology in 2011 stated that Luria Bertani halophilic microbial media was able to prevent coprecipitation, showed with NaCl purity in salt fields reached 98%. However, Luria Bertani media is expensive (Rp.7200,-/L brine 25OBe) and difficult to manipulate Consequently, it is necessary to find a cheaper and available substitute. This study aimed to develop the use of Artemia salina medium as subtitute for Luria Bertani media. This is a two stages experiment study. the first to develop media composition of Artemia salina. The second step the process of crystallization using the best substitute from the first step. The best composition of Artemia salina was 3.375 g, 1.5 g urea, with 4.5 g for each 1500 mL mixture sugar (1350 mL brine 25OBe +150 mL seed halophilic) The second showed that the product meets the requirements for iodized salt with NaCl content of 98%. Artemia salina based media is feasible to be used as a growth media for halophilic in the salt fields at a price of Rp.86, - / L brine 25OBe.